These benefits stem from proprietary defensin molecules that reactivate latent LGR6 stem cells in the basal layer of skin.

DefenAge Skincare’s 10 Luxe Hand & Body Cream with Age-Repair Defensins can reduce visible signs of skin aging (including the loss of hydration and elasticity) and visibly increase skin thickness, according to research published in the Journal of Cosmetic Dermatology.

In this open label, single-arm clinical study, subjects reported significant improvement across all subjective skin domains and objective measurements demonstrated improvement in cosmetic skin architecture, including visible improvement in elasticity, hydration, and appearance of skin thickness when the body cream was applied daily for six weeks. These benefits stem from proprietary defensin molecules that reactivate latent LGR6 stem cells in the basal layer of skin.

“Use of a Defensin-containing topical body cream resulted in the dramatic improvement in multiple skin qualities on challenging body areas including the hands, forearms, elbows, and knees,” says clinical investigator and principal author Kristen Echanique, MD, in a news release. “The stimulation of collagen and improvements seen in viscoelasticity and skin hydration were remarkable. Study participants also reported subjective improvements in dryness and discomfort, and in the appearance of the skin’s roughness, wrinkling, redness, age spots, and pigmentation.”