UV radiation (UVR) is known to improve psoriasis, but could it also impact markers of metabolic syndrome? Researchers recently reviewed the metabolic effects of exposure to UVR, with a focus on the effects of phototherapy protocols. The findings suggest potential benefit for phototherapy on LDL-cholesterol and inflammatory markers, like C-reactive protein and interleukin-6.

Twenty-five studies were identified that involved multiple types of UVR. Researchers noted that most studies recruited a small number of participants (≤100), who were middle-aged individuals undergoing treatment for psoriasis flare, with phototherapy or sun exposure advice administered for 12 weeks or fewer.

The authors say future studies should focus on determining whether the effects of these interventions change with time and are dependent on the source of UVR.

—Clin Biochem Rev; 40(3):147-162