Could serum levels of vitamin A predict risk of fungal infections among individuals treated with IL-17 inhibitors? Researchers (J Pharmacol Sci. (20)30059-1) theorize that supplementation of All-trans retinoic acid, recently shown to have direct fungistatic effect against Candida and Aspergillus Fumigatus, may benefit some patients.
Due to their modification of cytokine pathways, IL-17 inhibitors are associated with a potential increase in fungal infections. Researchers suggest that All-trans retinoic acid, an active metabolite of vitamin A, confers anti-inflammatory and immunoregulatory properties that may reduce the infection risk. The suggest screening levels of vitamin A to identify at-risk patients and supplementation in those who are deficient.