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Treatment Advances: The Role of PDE-4 Inhibitors in Dermatology

Jonathan Hale Zippin MD, PhD, Joshua Zeichner, MD, FAAD

In part 2 of his DermTube Journal Club interview, Jonathan Zippin, MD, PhD talks to host Joshua Zeichner, MD about advances in treating atopic dermatitis, psoriasis, and even itch. Dr. Zippin discusses the role of phosphodiesterase 4 (PDE-4) inhibitors in regulating cyclic adenosine monophosphate (cAMP) levels to help control symptoms of eczema, psoriasis, and itch. He says he's excited to have new, non-cortisone, safe treatment options, including crisaborole and apremilast, after years of working on mouse models and cell-based systems in the lab to understand how this signaling molecule functions in these disease states.

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