Study Shows No Association Between NSAIDs and BCC
04/18/2012
New data question an association between NSAID use and development of BCC, showing that NSAID use was not associated with subsequent incidence of BCC (HR = 1.04, 95% CI: 0.92–1.16) after adjusting for age, sex and estimated lifetime summer sun exposure among a cohort of 58,213 Caucasian Radiologic Technologists in the US (International Journal of Cancer; 130(12):2939-2948).
Subjects in the cohort had responded to the second and third of a series of three questionnaires (administered from 1994 to 1998 and 2003 to 2005, respectively). They reported no cancer at the time of the second questionnaire. BCC, constituent risk factors (e.g., eye color, complexion, hair color) and sun exposure history were assessed through self-administered survey. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards models. 2,291 subjects went on to develop BCC. There was no association based on on NSAID type or dose. Further analyses did not reveal interaction with sex, birth cohort, smoking, alcohol consumption, sun exposure, occupational radiation exposure or personal risk factors for BCC, according to the authors.