Makucell, Inc.'s Asymmtate(TM), the key ingredient in the Renewnt line, may reverse gene expression changes associated with aging skin and with lentigines. Findings for Asymmtate, a proprietary cosmetic ingredient that influences the gene co-activator choice used by ß-catenin to encourage skin stem cell differentiation, were presented in a poster at the Cosmetic Boot Camp in Colorado Springs, CO by Makucell's Vice President and Chief Medical Officer, Mark V. Dahl, MD and reported by the company. Results showed that application of a cream containing Asymmtate is associated with down-regulation of the gene expression of proopiomelanocortin (POMC) and up-regulation of melanocortin receptor (MCR1) in human skin compared to the base cream. Twelve subjects participated in the study, applying Asymmtate 0.75% cream to one upper extremity and vehicle base to the other twice daily for four weeks. POMC was down-regulated an average 93% among all 12 subjects and MCR1 was up-regulated an average 16% in eight of 12 subjects. By week 2, a blinded evaluator detected a statistically significant improvement in skin roughness on the active treatment sites.