Serum adipokines and T-helper 17-related Cytokines Associated in Psoriasis

October 25, 2012

New research suggests that adipokines and Th17 cytokines are involved in the pathogenesis of psoriasis. (Clin Exp Dermatol, E-pub) In patients with psoriasis, resistin levels were significantly positively associated with tumour necrosis factor-α, and there was a strong negative association between retinol binding protein-4 and interleukin (IL)-6 levels. There was also a marked positive correlation between IL-22 and adiponectin in patients with psoriasis. The study, which enrolled 30 patients with psoriasis and 30 normal controls, used ELISA to measure serum adipokines and Th17-related cytokines. Pearson correlation analysis was used to determine the association between each adipokine and each cytokine. Multiple regression analysis using all adipokines and Th17-related cytokines as covariates was also performed. Pearson correlation analysis showed a strong positive association between chemerin and resistin levels and between adiponectin and high molecular weight adiponectin in normal controls. Leptin levels correlated positively with IL-6 in patients with psoriasis, but this did not reach significance.

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