Alphaeon Corporation has launched PROVOQUE™ Facial Serum to help address the visible signs of skin aging.PROVOQUE Facial Serum is a stem cell-conditioned media containing growth factors secreted by stem cells. Packaged in an easy to apply cosmetic formulation, PROVOQUE Facial Serum is intended to improve the appearance of wrinkles, skin firmness, softness and radiance.

PROVOQUE Facial Serum has been developed by AiVita Biomedical Inc., a biotechnology company with a solid trajectory in stem cell research, and will be commercialized through Alphaeon Corporation, a social commerce company in lifestyle healthcare.

“Thanks to our unique in vitro culture system, PROVOQUE Facial Serum has over 25 stem cell-derived growth factors, which can help improve the appearance of the skin,” said Hans Keirstead, PhD, CEO of AiVita.  “The technology utilized in PROVOQUE is backed by two clinical evaluations confirming the product’s performance.”

The larger of the two studies will be published in this month’s issue of the Journal of Drugs in Dermatology: “Human Stem Cell-Derived Skin Progenitors Produce Alpha 2-HS Glycoprotein (Fetuin): A Revolutionary Cosmetic Ingredient.” The study examined the effect of human stem cell-conditioned media containing stem cell-derived growth factors on aged skin for 12 weeks. The results showed that the evaluated parameters (appearance of wrinkles, firmness, radiance, texture and softness) improved in as early as two weeks.  The appearance of wrinkles improved in as early as 14 days, with significant results after 56 days, according to data on file with Alphaeon.