Incidence rates of squamous cell carcinomas (SCCs) are increasing, particularly in high-risk populations, including fair-skinned or immunosuppressed individuals. Few therapeutic options exist to prevent sunlight-induced skin cancer despite rising incidence rates. A recent study determined that ablative fractional laser (AFL) treatment may have potential in prevention strategies for SCC and photodamage in high-risk populations.

The preclinical report, led by Uffe Høgh Olesen, MSc, PhD, is titled, “Repeated exposure to fractional CO2 laser delays squamous cell carcinoma formation and prevents clinical and subclinical photodamage visualized by line-field confocal optical coherence tomography and histology.” The report, published in Lasers in Surgery and Medicine (LSM), the official journal of the American Society for Laser Medicine and Surgery, Inc. (ASLMS), was selected as the November 2022 Editor’s Choice.

“In this preclinical study, we determined that ablative fractional laser could prevent ultraviolet radiation-induced damage to the skin and delay the formation of squamous cell carcinoma, a form of skin cancer,” said Olesen. “Ablative fractional laser may potentially serve as a prevention modality for populations with a high risk of developing skin cancer.”

Mice exposed to ultraviolet radiation were randomized to receive either AFL on dorsal skin or no treatment. The occurrence of SCCs and level of photodamage were assessed. The authors found a significant delay in tumor formation in AFL-treated mice compared to untreated controls. Further, AFL imparted photo-preventative effects in both the epidermis and dermis, including increased skin tightness, improved dermo-fiber structure, and normalization of skin thickness. In conclusion, the results suggest that AFL may have potential in prevention strategies for SCC and photodamage in high-risk populations.

Uffe Høgh Olesen, MSc, PhD, works as senior researcher at Copenhagen University Hospital – Bispebjerg, Department of Dermatology. His focus is translational research on the potential roles of energy-based devices in treatment of keratinocyte cancers with particular emphasis on laser-based devices, the immune system and immunotherapy.