UCB presented 11 abstracts on bimekizumab in the treatment of adults with moderate to severe plaque psoriasis at the 2022 American Academy of Dermatology (AAD) Annual Meeting in Boston, MA, including a late breaking oral platform presentation and 10 posters. The platform presentation details new analysis of pooled data from five bimekizumab Phase 3/3b clinical trials, which showed that more than 80 percent of patients who achieved complete skin clearance (PASI 100) at week 16 and entered the open-label extension (OLE) studies maintained this response through two years, and no new safety signals were identified.

Among the poster presentations, new data from the OLE period of the Phase 3b BE RADIANT study showed that clinical responses (PASI 100 and absolute PASI, PASI ≤2) achieved at week 48 were maintained through week 96 with continuous treatment with bimekizumab and improved for patients who switched from secukinumab to bimekizumab on entry to the OLE. Patients who were PASI 90 non-responders with secukinumab at week 48 achieved improved clinical responses (PASI 90 and PASI 100) after switching to bimekizumab in the OLE. Among patients who were PASI 90 responders with secukinumab at week 48, PASI 90 response was maintained and PASI 100 response increased following switch to bimekizumab in the OLE.

“Long-term complete skin clearance is an important goal for people with psoriasis, and the new 96-week data from the open-label extension period of the BE RADIANT study offer fresh insights on the sustained response and clinical potential of bimekizumab in moderate to severe plaque psoriasis,” ssaysaid Bruce Strober, MD, PhD, Clinical Professor, Department of Dermatology, Yale University School of Medicine, New Haven, CT, and Central Connecticut Dermatology Research, Cromwell, CT. “In addition, the improved clinical responses seen in patients who switched to bimekizumab after 48 weeks of treatment with secukinumab offer further new insights that should help to inform future clinical practice.” 

Emmanuel Caeymaex, Executive Vice President, Immunology Solutions and Head of US, UCB, adds: “We are pleased to share our latest long-term data on bimekizumab with the dermatology community at the 2022 AAD Annual Meeting. The wealth of new data, insights and progress being presented underlines our commitment to advances in psoriasis care for people living with this challenging, life-long condition.”