Nevisense Detects Skin Barrier Damage In Skin Samples

The new research suggests that Nevisense is an effective laboratory research device.

Nevisense can measure skin barrier function in human excised skin samples, SciBase reports.

For the study, Nevisense and its underlying Electrical Impedance Spectroscopy (EIS) technology were used to assess the effect of commercially available detergents on the skin barrier of mice and human skin samples. The top-line results of the study indicated that:

• EIS is a reliable biomarker/indicator of the skin barrier function in both ex vivo (lab research) and in vivo (human studies) models, with a higher sensitivity than trans-epidermal water loss (TEWL).
• EIS showed a significant correlation with protein biomarkers that are associated with inflammatory pathways.
• EIS further correlated with the expression of skin barrier-related genes.
• EIS is a fast and reliable tool for investigating skin barrier function in both ex vivo and in vivo models, with possible applications in dermatological and cosmetic studies.

"We are very encouraged to see that EIS measurements could identify skin barrier impairment at such an early stage and with high sensitivity. EIS provides an increasingly useful tool for such evaluations" says Professor Cezmi Akdis at  the Swiss Institute of Asthma and Allergy Research n Davos, Switzerland., in a news release.

"This publication represents a rewarding collaborative effort between several leading organizations in the skin barrier research space. We are proud of the technology underpinning the success of this project. Skin barrier research has grown rapidly to include diseases like eczema, psoriasis, allergic disorders, and many others.  We believe that Nevisense has the potential to become the state-of-the-art research tool within the skin barrier space, and now we can expand this to include ex vivo, in vivo, and human studies," says Pia Renaudin, appointed Chief Executive Officer of SciBase.

The full results of the study have appear in Allergy.