Novel Jasmonate Compound Takes On Fine Wrinkles, Pores

The active ingredient in Lancome’s Visionnaire family of products safely and effectively helps improve the appearance of fine wrinkles, skin tone and pores, according to a new study in the Feb. 2016 issue of the Journal of Drugs and Dermatology.

The ingredient, LR2412-Cx, is among the most widely studied jasmonate, a novel class of topical plant-derived anti-aging compounds. LR2412-Cx has been shown to upregulate hyaluronic acid, laminin-5, collagen IV, and  brillin in laboratory studies.  In addition, the application of LR2412 resulted in an increase in turnover and thickening of the epidermis, according to study author Macrene Alexiades MD, PhD, of the Dermatology and Laser Surgery Center, New York, NY.

The new study puts Visionnaire’s anti-aging effects to the test in 15 subjects with skin types I to IV.

Participants were evaluated by an investigator at baseline, day 1, day 3, and week 6 with the Alexiades comprehensive grading scale of skin aging, a novel pore-grading scale and subject quality of life assessments.

The mean (SEM) at baseline and at week six following twice-daily application were: for the appearance of wrinkles 2.91 (0.12) and 2.70 (0.10); for texture 2.91 (0.10) and 2.55 (0.10); and for pores 3.29 (0.08) and 2.46 (0.09), respectively, the study showed.  The differences in all three categories at all follow-up intervals were statistically significant (P<.005). The percentage improvement in investigator-assessed grades relative to baseline at day 1, day 3, and week 6 were: 2.3 percent, 4.9 percent, and 7.4 percent for the appearance of wrinkles, 5.7 percent, 9.4 percent, and 12.4 percent for texture, and 14.2 percent, 21.6 percent and 25.2 percent for pores, respectively. The treatment was also deemed safe.

This study was funded by a research grant from Lancôme.