Skin Microbiome Linked to GVHD Following Stem Cell Transplant in Leukemia

October 17, 2022

When the skin microbiome of folks with GVHD were analyze, there was a drastic decrease in bacterial abundance.

Organ damage occurs in up to 70 percent of patients in the first few months following stem cell transplant, but the precise reasons for this potentially life-threatening reaction haven’t been fully understood. Now, researchers led by Georg Stary from the Department of Dermatology at MedUni Vienna and Vienna General Hospital in collaboration with the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases show that bacterial proliferation on the skin is a factor associated with the occurrence of the complication. 

The findings are published in Leukemia and contribute to the research and development of new therapeutic approaches.

 The researchers examined the skin of 50 patients, most of whom had undergone stem cell transplant (SCT) for leukaemia at the Department of Bone Marrow Transplantation at the Department of Internal Medicine I at MedUni Vienna and Vienna General Hospital. In the first few weeks or months after receiving the stem cells from the donor, a donor-versus-recipient reaction (graft-versus-host disease, GVHD) occurred in some of the test subjects. When the skin microbiome of those affected were analyzed in detail, the research team led by first author Nadine Bayer and study leader Georg Stary from MedUni Vienna and Vienna General Hospital found a drastic decrease in bacterial abundance. "The reduction in proliferation was particularly pronounced in severe cases of GVHD - even before symptoms appeared," Stary  says in a news release. At the same time, the scientists observed an increased occurrence in patients with GVHD of staphylococci on the skin, i.e. bacteria that can cause serious infections.

Reaction almost always involves the skin

Despite precise examinations of the stem cell donors' and recipients' tissue characteristics as well as preventive medication, GVHD occurs in approximately 30 percent of patients after sibling donations and in approximately 70 percent of patients after donations from unrelated donors. This reaction means that body cells are attacked as foreign by immune cells that are newly developed from the transplant, and organs are subsequently damaged. The complication almost always affects the skin: the first symptoms are usually rashes, which, depending on the severity, can manifest themselves as slight redness or severely inflamed cutaneous changes with a detachment of the uppermost skin layer.

 The fact that the composition of the gut microbiome influenced the clinical course after stem cell transplantation was already known to medical researchers. With the identification of the skin microbiome in GVHD, the scientists have another tool at their disposal with which to research and develop improved treatment measures. "Follow-up studies will now show whether the change in the skin microbiome may contribute to the development of GVHD and whether new therapeutic approaches can be identified from the knowledge gained," says Stary.

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