Honey may play a role in wound healing due to its antimicrobial and tissue-regenerative properties.

Honey may play a role in wound healing due to its antimicrobial and tissue-regenerative properties, according to scientists from the University of Manchester.

Their review of more than 250 articles spans 85 years -with oldest article from 1937- is published in the journal Pharmaceutics.

 The sweet substance may offer an alternative to conventional antimicrobial drugs which are increasingly becoming ineffective in the face of growing resistance.

 However, more work is needed to identify and quantify the compounds that give honey its antimicrobial and wound healing properties to make it more reliable and standardized, the researchers conclude.

 Honey has been mainly used as a topical application on wounds for its antibacterial properties, resulting from its ability to generate hydrogen peroxide and the presence of other active compounds. The compounds include phenols, defensin-1, and methylglyoxal (found in manuka honey). Its acidity and low water availability also contribute to honey’s healing properties. Honey’s stickiness also provides an effective hydrated barrier between the wound site and external environment.

A variety of wound types have been treated with honey, such as burns, trauma, and chronic wounds.

Mesitran, one of the first line of products to incorporate medical grade honey in the UK, was launched in 2005 in Manchester.  In recent years, research has focused on using honey in tissue engineering applications.

Things like electrospun nanofibres, hydrogels and cryogels, foams, films, powders, cements, and bioinks have been utilised to fabricate honey-based scaffolds.  Moreover, some studies have shown how antibiotic-resistant bacteria can be more susceptible to antibiotics when used in tandem with honey.

In one paper included in the review, Methicillin-resistant Staphylococcus aureus (MRSA) was exposed to manuka honey in combination with oxacillin, and they acted together to desensitise the MRSA to the antibiotic.

 Honey’s antimicrobial activity also includes the ability to kill or slow the spread of fungi and viruses.

 Honey in combination with traditional wound dressings presents some limitations, such as being absorbed by the dressing, poor penetration into the wound site, and short-term antimicrobial action, the researchers note.

 However, manufacturers of impregnated dressings are attempting to improve their delivery mechanism to improve the efficacy of the substance.

 “Honey has exciting antimicrobial properties and has been used in traditional medicine to treat wounds since ancient times,” says lead scientist Joel Yupanqui Mieles, a postgraduate researcher from The University of Manchester in Manchester U.K, in a news release.

“The ancient Egyptians utilized it to treat wounds and there are direct references to honey consumption in the Bible and the Quran, [and] the compounds in honey offer a bank of potential antimicrobial and regenerative agents that can be utilized to combat antibiotic resistance and aid in tissue healing,” he says.

 “But though the repository of compounds within honey may have immense medical benefit, further research is required to understand more about how they work and how they can be delivered to wounds effectively and safely in a standardized way,” he says.  “Knowing the type and composition of honey used in different wound types will also improve the quality of research [and] allow scientists to make the most of honey’s antimicrobial and healing mechanisms.”

 This work may allow researchers to artificially replicate these in honey-inspired biomaterials that can be used with the current advances in tissue engineering technologies. “That would minimize risks around processing in terms sterilization, storage, transport and determining authenticity and safety,” he says. “One thing is certain: rising global antibiotic resistance is stimulating the development of novel therapies as alternatives to combat infections – and honey, we think, has a role to play in that.”