Study Analyzes Genes Targeted by NB-UVB for Atopic Dermatitis

Applied narrowband ultraviolet B (NB-UVB) radiation is likely a suitable therapeutic method for atopic dermatitis, according to a network analysis in the Journal of Lasers in Medical Sciences.

The study, undertaken by researchers in Iran, aimed to explore the critical genes that are targeted by NB-UVB radiation. The researchers extracted gene expression profiles of atopic dermatitis patients from the Gene Expression Omnibus database and analyzed them via protein-protein interaction network analysis to find the critical targeted genes.

Five central genes—SMC3, ARF3, EIF5B, SMARCB1, and LAPTM5—were highlighted as the critical genes responding to NB-UVB radiation in atopic dermatitis patients.

“The introduced crucial genes are involved in essential cellular functions such as apoptosis, cell cycle, cell proliferation, and inflammation,” the researchers wrote as they concluded that applied NB-UVB radiation “seems” to be a suitable therapy.