Xycrobe technology harnesses the power of a particular strain of Cutibacterium acnes subspecies defendens to improve the health and appearance of the skin by curating and supporting the right strain within the existing microbiome. 

Crown Aesthetics’ BIOJUVE regimen, which incorporates the patented Xycrobe technology, supports a healthy skin environment, promotes increased skin hydration, decreases redness, regulates sebum production and reduces the appearance of signs of aging such as fine lines and photodamage, according to a study in the Journal of Cosmetic Dermatology.

Xycrobe technology harnesses the power of a particular strain of Cutibacterium acnes subspecies defendens (C. acnes defendens), a subspecies of the most prolific skin-specific bacterial species, which accounts on average for 89% of the bacteria in the sebaceous skin follicles, to improve the health and appearance of the skin by curating and supporting the right strain within the existing microbiome. 

Subjects in this 8-week study used a 5 or 7 point Likert-scale (agree/neither/disagree) over a two month evaluation period. Agreement responses at the 90th percentile or higher included (improved) skin texture, tone, healthy, natural appearance, felt conditioned, radiant, and vibrant (n=121*). 

"The research we present in this paper debunks numerous myths that have perpetuated for the last half century or so about what constitutes a healthy skin microbiome, what role C. acnes strains play in skin health, and the ability to formulate progressive topicals with live microbes that might contribute to a healthier skin biome overall," says Dr. Thomas M. Hitchcock, PhD, Chief Science Officer, Crown Laboratories Inc., in a news release.  "We firmly believe that Crown Laboratories Inc. is pioneering the "skin biome care" category with our extensive research into the skin biome. We aim to continue to invest in exploring the relationship between the microbes that live on and in the skin, and how this new philosophy of formulating topicals to holistically consider the skin biome may change how we care for the skin. We believe Xycrobe technology fulfills the skin biome needs outlined by our research, and we are very excited to share this data and the BIOJUVE products used in the clinical study, with the world." 

"Traditionally, the medical focus for topical skincare products has always been placed on how any given ingredient may impact the overall health of skin cells with minimal consideration of how the ingredients impact the skin's microflora, or microbiome," says Dr. Doris Day, a New York City board-certified dermatologist and participant in the research study. "The proven efficacy of this patented Xycrobe technology reinforces the idea that the human body depends on symbiosis. I anticipate this research will diversify the way in which doctors address the health and treatment of skin conditions."