Systematic Review Suggests Anti-Inflammatory Effects of Astragalus membranaceus

Key Takeaways

• A systematic review of studies from 2015–2025 suggests Astragalus membranaceus may benefit aging skin with antioxidant and anti-inflammatory effects.

• Active compounds such as astragaloside IV appear to have a protective effect against oxidative stress, while promoting telomere elongation and collagen synthesis.

• Clinical trials indicate visible skin improvements, but randomized studies are required to evaluate efficacy and safety.

A new systematic review suggests the traditional botanical Astragalus membranaceus may have clinically relevant anti-aging benefits.

"The demand for cosmetic strategies to mitigate [skin aging-related] changes has grown in popularity, with more individuals seeking solutions to maintain a youthful appearance," the authors wrote in the study, published in the Journal of Drugs in Dermatology. "Among the various approaches to skin rejuvenation, natural plant-based agents, such as those derived from Astragalus membranaceus, have garnered attention due to their perceived safety and holistic benefits."

For the review, the researchers conducted a literature search of clinical and experimental studies published between 2015 and 2025 evaluating anti-aging properties of Astragalus membranaceus and its active constituents (astragaloside IV, cycloastragenol, flavonoids, and polysaccharides). Clinical trials included in the review reported improvements in skin hydration, tone, and wrinkle reduction. The study data revealed multiple mechanisms of action related to cutaneous aging, including reactive oxygen species (ROS) reductions, inflammatory signaling inhibition, mitochondrial protection, and collagen synthesis promotion. Additionally, astragaloside IV showed the ability to elongate telomeres under oxidative stress, which the authors noted had potential implications for both intrinsic aging and environmental damage. 

"Astragalus membranaceus offers promise as a botanical anti-aging agent," the authors concluded. "Its effects on collagen, oxidative defense, and telomere preservation support its potential use in cosmeceuticals. However, further randomized trials are needed to confirm long-term efficacy and safety."

Source: Jackson S, et al. Journal of Drugs in Dermatology. 2026;25(1):9157.