Matrikynes is comprised of a proprietary mixture of natural extracellular matrix-derived peptides called matrikines.

Xylyx Bio’s proprietary Matrikynes ingredient is safe and highly effective for anti-aging and other topical skin applications, a new study shows.

Matrikynes is comprised of a proprietary mixture of natural extracellular matrix-derived peptides called matrikines. The intrinsic bioactivity of matrikines has been shown to activate regenerative mechanisms that can drive tissue repair and reverse the effects of aging, the Company states.

The study evaluated the clinical safety and efficacy of Matrikynes for topical skin applications in 56 female volunteers, age 35 to 65, representing different skin types and tones. Standard dermatological assessments were performed using clinical instrumentation and validated measurement techniques. Safety testing showed no allergic sensitization or irritant reaction to Matrikynes, and topical application of Matrikynes significantly improved skin barrier repair. Moreover, topical application of Matrikynes increased skin density and decreased the appearance of global fines lines and deep wrinkles.

"As a pioneer in regenerative medicine, Xylyx Bio developed Matrikynes in response to the increasing demand in topical skincare for evidence-based ingredients that can effectively address skin damage and aging,” says Dr. John O'Neill, Chief Scientific Officer of Xylyx Bio, in a news release. “This study confirms that Matrikynes is safe and offers multiple functional and cosmetic benefits. Such significant reparative capabilities in a single ingredient pave the way for a new paradigm of regenerative skincare."

Results from the study are reported in the white paper "Clinical evaluation of Matrikynes®: a novel cosmetic ingredient comprised of matrikine peptides".