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In each issue, Practical Dermatology® magazine spotlights a new product that cosmetic physicians are introducing to their patients. Here, Natalie M. Curcio, MD, MPH, a dermatologist and the CEO and founder of Curcio Dermatology, PC in Nashville, TN, discusses DefenAge 360-Rejuvenation Nail Root Serum.

What is 360-Rejuvenation Nail Root Serum?

Natalie M. Curcio, MD, MPH:DefenAge’s 360-Rejuvenation Nail Root Serum is a novel product to treat nails by addressing the cause of the problem in the nail matrix. Nails grow faster, smoother, and harder with the first results noticeable in as soon as two to four weeks.

Please tell us about the actives in the Nail Serum.

Dr. Curcio: The serum contains Age-Repair Defensins, which are natural molecules known to awaken dormant regenerative cells in our body. Other actives include methionine, an essential amino acid that is a crucial building block of the nail, Tara Tree Fruit Extract (Caesalpnia spinosa), a natural antioxidant that is effective in protecting the nails and their keratin structure from damaging free radicals caused by environmental stress, ultraviolet light, and harsh chemicals, and Vitamin B Complex (niacinamide, panthenol, and biotin) to repair the natural moisturization of the nail and surrounding skin, revive oxygen supply, and activate nail keratin. Other actives include an extract from the flowers of “love in a puff,” a medical plant known as a cortisone-free alternative; Epigallocatechin Gallatyl Glucoside, a water-soluble form of one of the most active molecules found in green tea; and black currant seed extract.

What are the benefits of 360-Rejuvenation Nail Root Serum?

Dr. Curcio: DefenAge’s 360-Rejuvenation Nail Root Serum improves nail plate smoothness and reduces vertical and horizontal ridges. It increases nail plate strength to improve brittle nails and make nails less prone to splitting, peeling, and breaking. In addition, this serum increases the growth rate of the nail plate and improves the moisturization of the skin around the nail, improving chronically dry cuticles.

How does the 360-Rejuvenation Nail Root Serum compare with other topical nail treatments?

Dr. Curcio: All currently available nail treatments cosmetically mend the old nail plate with chemicals. DefenAge’s Nail Serum addresses the cause of the problem by targeting the nail-producing cells in the nail root with defensins and other ingredients to produce new, stronger, smoother, and rejuvenated nails. I have been waiting a long time to have an effective nail product that addresses the root cause of nail disease made from natural ingredients. Finally, it is here.

Who is a good candidate for 360-Rejuvenation Nail Root Serum?

Dr. Curcio: Many times, our nails get dry, brittle, or less smooth as we get older or from things we mechanically do to our nails. A topical product like DefenAge nail serum is ideal to improve our nail health by regenerating the nail in the nail root and getting us back to younger, healthier nails.

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